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中華民國泌尿科醫學會雜誌

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篇名 The Efficacy and Safety of Tamsulosin in Treating Symptomatic Benign Prostatic Hyperplasia
卷期 11:4
並列篇名 使用Tamsulosin治療攝護腺肥大症療效評估
作者 陳宗義吳東霖
頁次 155-160
關鍵字 良性攝護腺肥大症下泌尿道症狀尿路動力學阿爾發阻斷劑benign prostate hyperplasialower urinary tract symptomtamsulosinurodynamicsalpha-blockersTSCI
出刊日期 200012

中文摘要

目的:本研究目的在評估使用tamsulosin治療良性攝護腺肥大症之療效。材料及方法:總共30位攝護腺肥大症患者進入本試驗接受每日tamsulosin 0.2 mg治療。四週後分為三組:第一組維持原劑量繼續治療四周,第二組停藥四週,第三組增加為每日0.4mg。治療效果以國際攝護腺症狀評分,生活品質評分,及最大尿流速度評估。結果:二十七位患者有治療數據可供評估,19位在治療四週後有顯著改善。評估所有患者在治療四週後國際攝護腺症狀評分平均減輕7.7分,生活品質評分改善1.2分,最大尿流速度增加3.6毫升/秒。血壓變化在統計學上有意義,但臨床無意義。對0.2mg治療效果不佳的患者在劑量增加為每日0.4mg後有顯著改善,但血壓變化明顯。結論:根據我們有限的經驗,每日服用tamsulosin0.2mg似乎可有效治療良性攝護腺肥大症所導致之症狀並改善尿流速度;患者耐受性良好。

英文摘要

OBJECTIVE: The purpose of this open-label study was to assess the efficacy of tamsulosin hydrochloride in treating symptomatic benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: A total of 30 BPH patients was enrolled in this clinical trial with tamsulosin 0.2 mg once a day. After a 4-week initial treatment, patients were divided into 3 groups: 1) maintaining treatment for another 4 weeks, 2) discontinuing treatment for the following 4 weeks, and 3) doubling the dosage to 0.4 mg/day for 4 weeks. The efficacy of treatment was evaluated by International Prostatic Symptom Score (I-PSS), quality of life scores(QOL), and maximal urinary flow rate(Qmax). RESULTS: Twenty-seven patients had available follow-up data for analysis. Nineteen patients had significant response after 4-week treatment. When all patients were evaluated, mean decreases of I-PSS of 7.7 points and QOL of 1.2 points were noted at the 4-week visit. Qmax increased 3.6 ml/s over baseline values. Voided volume increased by 41 ml. A statistically but not clinically significant decrease in blood pressure was noted. For patients not responding to 0.2 mg tamsulosin, significant improvements in I-PSS and Qmax were achieved after increasing the dosage to 0.4 mg/day. However, significant decreases in systolic and diastolic blood pressure were encountered. CONCLUSIONS: In our series, tamsulosin hydrochloride 0.2 mg once a day was an effective treatment for symptomatic BPH with good tolerability.