膀胱外翻是一種相當罕見的先天異常。從1970年代開始利用皆段式手術來矯正此先天異常，其目的鄉於(1)確保關閉腹壁(2)重建排尿功能，保存腎功能(3)在男性病人要重建陰莖(4)避免將來發生癌症。本文報告一位44歲女性病人患有膀胱外翻病史，入院4個月前發現下腹腫塊，經膀胱切片證實為腺細胞癌，臨床上已有疑似淋巴轉移，於是為她施予骨盆腔前部臟器根除術合併迴腸尿路迴流及兩側腹股溝淋巴摘除術。根據文獻報告膀胱外翻合併腺狀細胞癌的病例相當少見，在未縫合的膀胱外翻病人有4至7.5%幾率會發生膀胱腺細胞癌，而一縏定者認為膀胱腺細胞癌必需實行根除性膀胱切除術。此病患在31歲時才接受發生膀胱外翻縫合術，13年後不幸地發生膀胱腺細胞癌。因此我們認濕膀胱外翻的病人應在出生時即開始接受治療，且術後必須接受長期追蹤檢查。

Bladder exstrophy is a rare congenital malformation with incomplete fusion of the mesoderm. Since early 1970s, treatment recommended has been to preserve renal function, gain continence of uringe, reconstruct the external genitalia and avoid cancer. Recently we treated a 44-year-old female with adenocarcinoma of the urinary bladder. She was born with bladder exstrophy and was treated with primary closure 13 years ago. Malignant change was diagnosed in February 1995. Radical surgery was performed, followed by palliative radiotherapy. Advanced stage was noted by pathologic examination. Unfortunately, she died one year later due to extensive metastasis. (J Urol R.O.C., 8:202-205,1997)