為了研究經尿道攝護腺針刺燒灼術（TUNA）的效果及安全性，我們以此方法治療了6位有症狀的攝護腺肥大病患，另外我們亦隨意選擇了同時期接受經尿道攝護腺切除術（TURP）的6位病患結果來做為比較。這12位病患的年齡從63歲到78歲（平均70.5歲），術前的評估包括肛門指診，美國泌尿醫學會症狀評分表，尿流速，血中攝護腺特異抗原，經肛門超音波及膀胱鏡的檢查。在經尿道攝護腺針刺燒灼術的這一組，除了前2位病患是以脊椎麻醉完成外，另外4位病患都是接受局部麻醉及靜脈鎮靜劑注射。這些病患無論是接受經尿道攝護腺針刺燒灼術，或是經尿道攝護腺切除術，都能順利的完成手術。在經尿道攝護針刺燒灼術的6位病患，術後追蹤超過3個月的結果為：最大尿流速從11.5+4.8毫升/秒增加到12.1+1.9 亳升/秒；同時美國泌尿醫學會症狀評分表也從26.2+7.3進步到18.8 + 4.3。在經尿道攝護腺切除術這一組，術後3個月追蹤，最大尿流速從15.5+6.7亳升/秒增加到19.5+4.8 亳升/秒，同時美國泌尿醫學會的症狀評分表也從25.8+9.2進步到13.3+2.8。在經尿道攝護腺針刺燒灼術這一組，這6位病患後都有輕微的血尿，其中4 位有尿滯流而需留置道尿管2至14天，平均7天。轂之，初步的結果顯示，經尿道針刺燒灼術是治療攝護腺肥大的一有效且安全的方法。然而，其初步結果並不如經尿道攝護腺切除術的效果好。

To investigate the effectiveness and safety of transurethral needle ablation of prostate (TUNA), these procedures have been used for the management of six patients with symptomatic benign prostatic hyperplasia (BPH). Another six patients who underwent transurethral resection of the prostate (TURP) were also enrolled in this study as a comparative group. These 12 patients were from 63 to 78 years (mean: 70.5) old. Preoperative evaluation included digital rectal examination, American urological association (AUA) symptom scoring, uroflow rate, serum prostate specific antigen (PSA), transrectal ultrasonography and cystourethroscopy. In the TUNA group, the initial two patients were treated under spinal anesthesia and the other four were under topical anesthesia and intravenous sedation. All of the patients who underwent either TUNA or TURP tolerated the procedures well. In the TUNA group, all six patients have been followed up for more than three months. The mean peak flow rate increased from 11.5 ± 4.8 to 12.1 ± 1.9 mL/s and the mean AUA symptom score improved from an average of 26.2 ± 7.3 to 18.8 ± 4.3. In the TURP group, peak flow rate increased from 15.5 ± 6.7 to 19.5 ± 4.8 mL/ s, and AUA symptom score improved from 25.8 ± 9.2 to 13.3 ± 2.8 three months after operation. In the TUNA group, mild hematuria was found in all patients. Urinary retention developed in 4 patients, and urethral catheterization was needed from 2 to 14 days (mean 7.0). In conclusion, these preliminary results suggest that TUNA is an effective and minimally invasive procedure for the treatment of BPH. However, the early effect of TUNA is not equivalent to TURP.