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中華民國泌尿科醫學會雜誌

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篇名 Use of Dimethylsulfoxide in the Treatment of Interstitial Cystitis
卷期 5:3
並列篇名 利用膀胱內灌注Dimethylsulfoxide (DMSO) 來治療間質性膀胱炎的病人
作者 余宏政丘祖毅賴明坤
頁次 157-162
關鍵字 間質性膀胱炎尿路功能檢查interstitial cystitisDimethylsulfoxideurodynamicsTSCI
出刊日期 199409

中文摘要

為了解膀胱內灌注DMSO對於間質性膀胱炎的治療效果,共有19個女性間質性膀胱炎的病人接受了每隔星期膀胱內灌主50ml,50% DMSO的治療。這些病人的平均年齡為47.6歲,平均患病時間為23.8個月。經過6次治療後,我們以病人的主觀病狀改善程度及膀胱功能的變化六估治療的效果。共有15個病人完成這個研究,其中8個病人(53.3%)獲得病狀改善。(DMSO)治療可減少排尿次數,增加排尿量,但對於尿路功能檢查的灌注感覺及膀胱肉容並無顯著。這種治療的副作用很輕微,有6例病人覺得膀胱在藥物灌注後幾小時內有局部燒灼感,有1例病人得有短暫的頭暈。這8個有效的病人在門診斷續蹤6到20個月,其中6個病人需要間斷性的DMSO,其中有4個病人最後變得無效而需要改用其他的治療法。從這個研究我們發現DMSO在短期使用可以改善間質性膀胱炎病人的症狀。雖然其長期的效並不理想,但考慮其方便性及低毒性,在使用其它侵犯的方法來治療間質性膀胱炎的病人之前,膀胱褲灌注DMSO是可先行使用的方法之一。

英文摘要

A prospective study was conducted to evaluate the efficacy of intravesical dimethysulfoxide (DMSO) in the treatment of patients with interstitial cystitis (IC). Nighteen female patients with clinical evidences suggestive of IC received intravesial instillation of 50ml 50% DMSO every two weeks for six sessions. Response was assessed subjectively and urodynamically. Of the 15 patients completing this study, the subjective improvement rate was 53.3% (8/15) DMSO treatment caused a significant decrease in voiding frequency (16.9±6.1 vs.19.7±4.8, p<0.05) and an increase of voided volume(136.9±40.1 ml vs. 107.4±35.9 ml, p<0.05), but not of first sensation of filling (119.5±19.9 ml vs. 112.7±20.7 ml, p>0.05) and cystometric bladder capacity (240.0±54.1 ml vs. 227.9±51.5 ml, p>0.05). Side effects included six instances of local irritation and one headache. The follow-up was 6 to 20 months, with 6 of the responders requiring further intermittent instillations of DM-SO. Eventually, four of them failed to respond to DMSO instillation and other treatments were resorted to. From this study, it was concluded that while intavesicular DMSO can help patients with IC in short-term follow-up patients gradually become refractory to this type of therapy.

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