自1984年到1992年，四十四位患有單側良性腎上腺腫瘤的患者，接受單側腎上腺切除術，患者的術前術後血壓的變化加以分析。其中四十位患者依其功能性診斷，可類分為原發性醛類脂醇過多症，庫欣氏徵候群及嗜鉻細胞瘤，此三類患者手術後，高血壓有明顯的改善，其改善狀況並能持續，經過一年的追蹤，71.4%患者的高血壓回復正常。25.7%有輕度高血壓，只有2.9%仍有持續的高血壓。高血壓的改善程度及患者恢復正常血壓的比例以嗜鉻細胞瘤患者最為明顯，而在原發性醛類脂醇過多症及庫欣氏徵候群患者中其血壓改善則較緩慢，但結果仍相當滿意。只有四位患有高血壓的患者，經電腦斷層攝影及功能性腎上腺核掃瞄，證明患有單側腎上腺腫瘤，但其功能上，無法作臨床分類，此四位患者在接受腎上腺切除後，其中一位恢復正常，另多三位只有短暫的改善，不久後，血壓再回升到手術前的高血壓，結果令人失望，其潛在發病的機轉，有待進一步的探討。

Forty-four patients with hypertension who were diagnosed with benign adrenal tumor (adenoma or hyperplasia) underwent unilateral adrenalectomy from 1984 to 1992 and were followed long-term. Forty of the 44 with a definite functional diagnosis (such as primary aldosteronism, Cushing’s syndrome and pheochromocytoma) had dramatic improvement of their hypertension immediately after the surgery, and this recovery persisted. After one year of follow-up, 71.4% became normotensive, 25.7% had mild hypertension and only 2.9% had persistent hypertension. The improvement in the hypertension and the percentage of patients who returned to normal was most notable in those with pheochromocytoma. The improvement in blood pressure was more gradual in patients with primary aldosteronism and Cushing’s syndrome. Four patients with hypertension only were found to have either adrenal adenoma or hyperplasia. On functional evaluation, they were not found to have any definite endocrinologic abnormality. Unilateral adrenalectomy resulted in only temporary improvement in three of these patients, and all four remained hypertensive on long term follow-up.