Based on cancer registration date, the incidence of bladder cancer in Blackfoot Disease (BFD) endemic area was estimated. The annual incidence of bladder cancer in this area during the period 1981 and 1985 was 23.53% per 100,000 population. This is a new of the highest incidence areas of bladder cancer in the entire world. Where patients with bladder cancer lived during was analyzeds only to find these years that therer existed “high risk villages”, "low risk villages" and "villages with sporadic cases" of bladder cancer in BFD endemic areas. From the geographic distribution of villages or "high risk" for bladder cancer, this disease was found to be distributed in the endemic area, rather scattered along two rivers and near the sea-side. Any relationship between the carcinogen's distribution and the existence of “high risk villages” needs to be further investigated.