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中西整合醫學雜誌

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篇名 登革熱的中醫治療- 文獻回顧與研究
卷期 20:2
並列篇名 Chinese Herbal Medicine for Dengue Fever Management — Literature Survey
作者 林恂怡黃國欽
頁次 028-038
關鍵字 登革熱中醫藥治療溫病Dengue fevertraditional Chinese medicinewarm diseases
出刊日期 201812

中文摘要

背景: 登革熱目前是世界上嚴重的蟲媒傳染病之一,目前西醫的治療方式主要為支持性療 法例如輸液及輸血治療,尚未發展出抗病毒藥物。本文目的為探討登革熱的古今中 醫藥治療,希望給登革熱的病患更全面的醫療照護。 材料與方法: 我們收錄2008-2018 年間出版的文獻:八篇台灣本土疫情資料及疫區當地中 醫院治療經驗、十七篇大陸當代醫家期刊論文及五篇現代研究關於中藥對抗 登革熱的有效成份報導,統計登革熱的相關古籍文獻指引、常見證型、治則 方藥等,總結了登革熱的中醫治療進展。 結果: 在三十篇中外的文獻中,有十七篇提及登革熱的中醫治療。根據統計結果,最常被 引用為治療指引的中醫理論為「溫病學說」。登革熱最常出現的四種證型為衛氣同 病、濕熱中阻、氣營( 血) 同燔及氣分熱盛。最常用的處方分別為銀翹散、三仁湯 與達原飲、清瘟敗毒飲及白虎湯。在現代藥理研究中,有一些從清熱類、芳香開竅 類中藥衍生的化合物,像是黃芩素、Diasarone-1、木犀草素、甘草次酸、金銀花的 水萃取物等,能藉由抑制病毒複製、成熟與突變等作用,減少登革熱病毒的感染致 病能力。關於中醫藥治療登革熱的臨床療效,值得進一步研究。

英文摘要

Background:Dengue fever is currently one of the world´s major insect vector epidemic disease, it reaches peak season during July to September in Taiwan. At present, the conventional treatment of dengue fever is supportive care, anti-viral drug or vaccination is still lack. This article aims to explore the syndrome ╱ pattern characteristics and management of dengue fever in Chinese herbal medicine (CHM). Materials and Methods: This paper collected and analyzed eight articles of Taiwan endemic disease treatment experience, as well as seventeen articles related to CHM management of dengue fever from Chinese Journal Full-text Database and five articles from PubMed which majorly published between 2008 and 2018. Results: Mentioned in the seventeen of the above thirty articles, dengue fever belongs to “warm diseases"in traditional Chinese medicine (TCM) according to its clinical manifestations. The most common syndrome ╱ pattern types and most popular treatment formula are“ dual disease of defense and qi" managed by Yin-Qiao-San“, blockage of damp-heat" managed by Da-Yuan-Yin and San-Ren-Tang“, dual blaze of qi , construction and blood" managed by Qing-Wen-Bai-Du Decoction,“ exuberant heat in the qi aspect" managed by Bai-Hu-Tang. In modern pharmacological research, some pure compound such as Baicalein, Luteolin, Carbenoxolone disodium and Diasarone-1extracted from single herbal medicines belonged to classes of “heat clearing"and“to open the orifices with aroma", were potential therapeutic intervention against dengue virus. Conclusions: Dengue fever has its own particular evolution with obvious seasonal and epidemic characteristics, CHMs have potential in treating dengue fever.

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