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Annals of Nuclear Medicine and Molecular Imaging

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篇名 Does Image Time Affect Semi-Quantitative Result of Gallium-67 Renal Scan?
卷期 14:3
並列篇名 造影時間會影響半定量鎵-67腎臟造影嗎?
作者 蔡世傳藍忠亮林萬鈺王世楨
頁次 143-147
關鍵字 鎵 67腎臟造影半定量造影紅斑性狼瘡腎炎67Ga scintigraphyLupus nephritisSemi quantitative method
出刊日期 200109

中文摘要

背景:鎵-67腎臟造影已被證實對評估紅斑性狼瘡腎帶的活性和其對治療的反應有不錯的效果。鎵-67造影時間通常介於注射藥物後48和72小時之間,本研究的目乃在評估造影時間對半定量鎵-67腎臟造影之影響。
材料的與方法:本研究包括122紅斑性狼瘡腎炎病患。在注射111MBq(3 mCi)的鎵-67檸檬酸鎵後48和72小時均接受鎵-67腎臟造影。電腦處理時,興趣區選在左腎、脊椎和左前手臂。計算出Kidney/Spine ratio (K/S ratio)或Kidney/Arm ratio (K/A ratio)。
結果:K/S ratio和K/A ratio兩種定量法在48小時和72小之比值均呈現相當好之相關性。左側K/S ratio的平均值在48小時影像中為0.969,在72小時則為0.964沒有統計上的差異(P=0.241)。相反地,K/A ratio的平均值在48小時影像中為3.421,在72小時則為3.574有統計上的差異(P=0.000043)。
結論:本研顯示左則K/S ratio在48小時和72小時影像之間,沒有統計上的差異。然而,K/A ratio則明顯地受到造影時間不同而有差異。

英文摘要

Purpose: Gallium renal imaging has been reported to be useful in monitoring disease activity and predicting the response to therapy in lupus nephritis. Gallium imaging is usually performed 48-72 h following administration of the 57Ga-citrate. The aim of the present study was to determine whether the imaging time affects the semi-quantitative results of gallium renal scintigraphy.
Methods: One hundred and twenty-two patients with lups enphritis underwent gallium renal imaging at both 48 h and 72 h post injection of 111 MBq (3mCi) 57Ga-citrate. For semi-quantitative analysis the gallium uptake in the kidneys, regions of interest (ROI) were drawn over the left kidney, the left forearm and the adjacent spine. The uptake ratios were calculated and expressed as "Kidney/Spine ratio (K/S ratio)" or "Kidney/Arm ratio (K/A ratio)".
Results: The correlation of both the left K/S ratios and the left K/A ratios from the 48-h and 72-h renal images was excellent. The mean left K/S ratio obtained from 48-h and 72-h images was 0.969 and 0.964 (P=0.241). Whereas, the mean left K/A ratio from 48-h and 72-h images was 3.421 and 3.547 (P=0.000043).
Conclusions: There is no statistical difference of the lift K/S ratios from 48-h and 72-h images. However, the left K/A ratio was significantly affected by the imaging time.

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