前言：本研究在於評估碘-131-MIBG及CT影像檢查封於嗜鉻性細胞瘤之定位價值、方法：本研究回溯性分忻19S7至1999年間，本院25位嗜鉻性細胞瘤病人。所有病人皆接受碘、131-MIBG造影及CT檢查。其間隔約為一星期。所有病人皆經病理報告證實為嗜鉻性細胞瘤。
結果：其中22人(88%)其嗜鉻性細胞瘤位單例腎上腺，另3人(12%)位腎上腺外。CT整體敏感度為96%(24/25)，碘-131-MIBG造影整體敏感度為80%(二(20/25)。CT未能偵測一位於膀胱周圍之病灶，另誤判另二處病灶為嗜鉻性細胞瘤(特異性：92%)。碘-131-MIBG造影未能偵測五處病灶，其中三位病人造影時服用labctalol。乃二處病灶大小小於3(3(3公分。碘-131-MIBG造影無偽陽性結果(特異性：100%)，合併此二種影像方法可正確地偵測所有嗜鉻性細胞瘤。
結論：碘-131-MIBG及CT造影對於定位嗜鉻性細胞瘤具互補效果。在腹部，CT有較好的敏感度。而碘-131-MIBG造影對CT的發現可特異性、功能性地加以證實，且可掃描全身，對腎外嗜鉻性細胞瘤打特別的偵測效果。

Background: This study aimed to evaluate the efficacy of iodine-131 meta-iodobenzylguanidin (131I-MIBG) scintigraphy and computed tomography (CT) in localization of pheochromocytomas. Methods: We retrospectively evaluated 25 patients with pheochromocytomas in our hospital during 1987-1999,All of these patients received 131I-MIBG scintigraphy and CT examinations within one week. The pathologic confirmations were obtained in all of the patients.
Results: Pheochromocytomas were localized in unilateral adrenal gland in 22 patients (88%) and in extra-adrenal in 3 patients (12%). Overall sensitivity of the studies was 96% (24/25} for CT and 80% (20/25) for MIBG, CT failed to detect one perivesical lesion, and falsely detected two other lesions as pheochromocy-tomas (specificity 92%). MIBG scintigraphy failed to detect five lesions; three of these lesions were imaged while the patients were on labetalol therapy and the other two tesions were smaller than 3×3×3 cm in size.There were no false positive results by MIBG scintigra-phy (specificity 100%). Combined use of these two imaging procedures correctly detected all of these pheochromocytomas.
Conclusions: MIBG scintigraphy and CT are complementary in the localization of pheochromocytoma. CT has greater sensitivity than MIBG scintigraphy in abdomen sites. However, MIBG scintigraphy can pro-vide specific functional confirmation of the CT findings and has the ability to screen the entire body, which is especially useful in the detection of extra-abdominal disease.