篇名 | Radiochemical Characteristics and Biodistribution for 99mTc Labeled Complexes with Schiff-Base Ligands Containing the ONNNO Donor Atom Set |
---|---|
卷期 | 15:1 |
並列篇名 | 鎝-99m標幟合二氧三氮席夫鹼錯合物之放化特性與生物分佈 |
作者 | 邱奕杭 、 鄭涵文 、 羅建苗 |
頁次 | 33-41 |
關鍵字 | 99mTc 、 biodistribution 、 radiochemical characteristic 、 Schiff-base with ONNNNO donor 、 鎝-99m 、 生物分佈 、 放化特性 、 二氧三氮席夫鹼 |
出刊日期 | 200203 |
本研究合成一系列含二氧三氮席夫鹼的配位子,係由水楊醛與三胺化合物如二乙烯三胺、二丙烯三胺及乙烯丙三胺與其對應物質惟在中闊氣位置上另鍵結有吭喀啶基等化合物反應衍生而得。鎝-99m錯合反應係在室溫下以酒石酸亞錫還原過鎝酸鈉,在不同的酸鹼值緩衝溶液下,加入配位子溶液,作用完成。我們以溶劑萃取、薄膜層析及紙帶電泳動對此一系列鎝-99m標幟錯合物進行放化特性分析,並以C3H/HeN小鼠針對其中四種鎝99m標幟錯合物進行生物分佈試驗。最後對這些鎝-99m錯合物之放化特性與生物分佈之中目關性作一討論。
A series of analogues of Schiff-base containing the 01IIII10 donor atom set were synthesized deriving from the reaction of salicylaldehyde and the triamine compounds of diethylenetriamine, diproplylenetriamine, and ethylene propylenetriamine, and the correspondent triamine compounds but bearing with middle N-bonded pyridinyl. Complexations were made at ambient temperature by reaction of the ligands with 99mTc-pertechnatate in the presence of stannous tartrate solution under different pH buffers. The radiochemical characteristics of the 99mTc-labeled complexes with the various ligands were investigated by the techniques of solvent extraction, thin layer chromatography and paper electrophoresis. Biodistribution of four 99mTc labeled complexes were studied on C3H/HeN mice. Correlation of biodistribution with radiochemical characteristics for the 99mTc labeled complexes is discussed.