背景:本研究之目的在於比較鉈-201草光子斷層乳房閃爍造影發現與Ki-67及p-醣蛋白表現在乳癌上的相關性。

方法:進行手術或切片之前，24位乳癌病患接受了鉈-201單光子斷層乳房閃爍造影並計算其腫瘤 背景比值，並利用免疫組織化學分析測定其Ki-67及p-醣蛋白之表現。

結果:11位具有Ki-67表現乳癌病患，其腫瘤背景比值明顯高於13位無Ki-67表現者(4.26± 0.41對2.25 ± o.刃，p <0.05) ，然而8位具有p-醣蛋白表現及16位無p-醣蛋白表現，其腫瘤背景比值則無明顯差異(3.52± 0.40對3.42 ± 0.45 ' P >0.05)。

結論:利用鉈-201單光子斷層乳房閃爍造影計算腫瘤單背景比值可用於預估Ki-67於乳癌上的表現。

Purpose: The aim of this study was to compare single photon emission computed tomography (SPECT) mammoscintigraphic findings of thaliium-201 (TI)with the expression of Ki-67 and P-glycoprotein (Pgp) in breast cancers

Methods: Twenty-four patients diagnosed with infiltrating ductal breast cancer underwent 201TI SPECT mammoscintigraphy before surgery or biopsy to calculate tumor to background (T/B) ratios. Ki-67 and Pgp expressions were measured by immunohistochemical analyses on multiple nonconsecutive sections from surgery or biopsy specimens of breast cancers. Results: The T/B ratios were significantly lower for tumors in 11 patients with positive Ki-67 expression than for those in 13 patients with negative expression (4.26 ± 0.41 vs. 2.25 ± 0.33， P < 0.05). However， differences in T/B ratios of 8 patients with positive Pgp expression (3.52 ± 0.40) and 16 patients with negative Pgp expression (3.42 ± 0.45) were insignificant in this study (P>0.05).

Conclusions: Our results suggest that T/B ratios calculated from叫TI SPECT mammoscintigrapy are useful for predicting the presence of Ki-67 expression in breast cancers