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| 篇名 | 奈米粒子之粒徑大小與高分子表面接枝密度對於蛋白質吸附、細胞吞噬與器官累積之影響 |
|---|---|
| 卷期 | 32:1-4 |
| 並列篇名 | The Effect of Polymer Grafting Level and Particle Size on Protein Adsorption, Cellular Uptake and Organ Distribution |
| 作者 | 駱俊良 、 蔣伊婷 、 羅尹彣 |
| 頁次 | 036-041 |
| 關鍵字 | 奈米粒子 、 聚乙二醇 、 蛋白質吸附 、 細胞吞噬 、 器官累積 、 nanoparticles 、 poly 、 protein adsorption 、 cellular uptake 、 organ distribution |
| 出刊日期 | 201007 |
中文摘要
本研究製備具40 nm與70 nm之經聚乙ニ醇修飾後奈米金粒子，探討奈米粒子粒徑大小與聚乙ニ醇接枝密度對於蛋白質吸附、細胞吞噬與器官累積之影響。研究顯示：蛋白質吸附量與兩者較無關係，細胞吞噬量與粒徑大小有關，而器官累積與粒徑及聚乙ニ醇接枝密度皆有關連。但腫瘤累積僅與粒徑大小相關。
英文摘要
PEG-modified gold nanoparticles with diameters of 40 nm and 70 nm were prepared to elucidate the effect of extent of PEG grafting and particle size on tumor accumulation and cellular uptake. Flow cytometry reveals that cellular uptake is strongly related to the size of PEG-modified GNs, rather than the extent of PEG grafting level. Also, particle size, rather than PEG grafting level affects tumor accumulation. However, PEG grafting level significantly affects the accumulation of particles in the liver and spleen.
This finding is important in determining the proper PEG grafting level and particle size for designing nano-medicines.