篇名 | 食品摻加西藥成分檢驗方法之探討(1)--類固醇類、減肥類及安眠鎮靜類 |
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卷期 | 12:1 |
並列篇名 | Adulteration of Drugs in Food (Ⅰ)--Glucocorticoids, Anorexics and Hypnotic-Sedatives |
作者 | 蔡芳英 、 魏念慈 、 吳珍瑗 、 陳玉盆 、 溫國慶 |
頁次 | 84-96 |
關鍵字 | 食品 、 類固醇類 、 減肥藥類 、 安眠鎮靜藥類 、 薄層層析法 、 紫外光分光吸光法 、 最適偵測濃度 、 Food 、 Glucocorticoids 、 Anorexics 、 Hypnotic-sedatives 、 TLC 、 UV 、 Optimal detection concentration 、 MEDLINE 、 Scopus 、 SCIE |
出刊日期 | 200403 |
In this study, we evaluated the adulteration of glucocorticoids, anorexics as well as hypnotic-sedatives in food products that claim to have medicinal effects and/or are assigned to specific category of drugs. The possible addition of drugs in food was also investigated. The TLC method was established to identify the components of each drug category using UV spectra obtained from TLC analysis. LC/MS and GC/MS were used to determine the optimal detection concentration of each drug by mixing the three placebo foods with drugs in 3 categories respectively. This paper shows the capability of the analytical method tested on the simulated food samples. Results showed that the optimal detection concentration of the three drug categories obtained are as follows: the concentration range of 7 ingredients of glucocorticoidsis from 1.25 mg/g prednisolone to 2.5 mg/g triamcinolone; 6 ingredients of anorexics is from 1.25 mg/g diethylpropion to 2.5 mg/g phentermine, 12 drugs of the third category is from 0.1 mg/g methaqualone to 3 barbitals (0.4 mg/g). The Standard Operating Procedures (SOPs) for the screening method, the UV spectra and the concentration of each drug offered as references for the qualitative method for the analysis