目的：鉈－201單光子射出斷層造影已知可用於偵測食道癌。本研究之目的是爲了進一步判別鉈－201的吸收與病理檢查發現的相關性。方法：本研究回溯分析19位於食道切除手術前已完成鉈－201單光子射出斷層的食道癌病人，就鉈－201吸收程度與術後病理檢查發現，包含腫瘤直徑、腫瘤侵犯深度及腫瘤分化程度進行比較。結果：腫瘤侵犯深度和鉈－201吸收程度呈現中度正相關性，而腫瘤直徑或腫瘤分化程度和鉈－201吸收程度並無明顯相關性。結論：以上三種病理檢查發現，只有腫瘤侵犯深度和鉈－201吸收程度具有統計顯著相關性。由於其非侵犯性的特性，用於篩檢無症狀高危險群以作早期診斷改善預後有潛在功效。

Purpose: Thallium-201 (201Tl) SPECT is a useful modality in detecting esophageal cancer. The purpose of this study is to further evaluate the relationship between 201Tl SPECT and pathological findings. Methods: Nineteen patients who had undergone 201Tl SPECT before esophagectomy were retrospectively enrolled for analysis. Results: There was a statistically significant positive correlation between the degree of 201Tl uptake and the depth of tumor invasion. However, there was no obvious correlation between 201Tl uptake and tumor size or grade of cell differentiation. Conclusions: For several characters of primary site of esophageal cancer, only depth of tumor invasion statistically significantly correlated with tumor uptake of 201Tl, which may afford a non-invasive method to screen early-stage disease in high-risk individuals.