篇名 | Variability in the Frequency of Single Nucleotide Polymorphisms of N-acetyl Transferase 2 (NAT2) Gene among the Different Ethnic Groups in Taiwan |
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卷期 | 16:5 |
並列篇名 | 臺灣不同族群間N-乙醯轉移?2(NAT2)基因單一核甘酸多型性的分布變異 |
作者 | 林慧玲 、 陳韻儒 、 林媽立 、 陳恆德 、 沈麗娟 |
頁次 | 15-20 |
關鍵字 | N-acetyltransferase 2 、 Aboriginal 、 Single nucleotide polylmorphism 、 Taiwan 、 N-乙醯轉移?2 、 原住民 、 單一核甘酸多型性 、 臺灣 、 MEDLINE 、 Scopus 、 SCIE |
出刊日期 | 200810 |
Significant variations in the frequency of single nucleotide polymorphisms (SNPs) of human leukocyte antigen among Taiwan’s aboriginal tribes and high homogeneity within each tribe have been reported. To identify variations in genetic polymorphisms of drug-metabolizing enzyme in seven of Taiwan’s ethnic groups, the SNPs of N-acetyl transferase 2, a conjugation enzyme in phase II metabolism, were investigated. Methods: Three SNPs of NAT2, NAT2*5, NAT2*6, and NAT2*7, were determined by the TaqManR method and subsequently confirmed by polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP). Our results showed statistically significant variations in the frequency of NAT2 genotype categories according to the 3 SNPs of NAT2 within 7 Taiwanese ethnic groups (Chi-square = 32.08, p<0.05). The distribution of the frequency of the slow acetylator genotype ranged from 32.0% in the Hakka population to 75.5% in the Paiwan population. A lack of NAT2*5 SNP alleles was found in the Atayal population, while a NAT2*5 allele frequency of 31.6% was observed in the Paiwan group. The frequencies of allele NAT2*6 and NAT2*7 in the investigated ethnic groups ranged from 11.2-37.0% and 17.0-53%, respectively. Our results also showed the considerable variations in drug-metabolizing enzyme NAT2 genotypes among Taiwan’s aboriginal and general population. The variation in the genetic polymorphisms of drug-metabolizing enzyme in Taiwan’s groups is worthy of further study to understand different therapeutic and adverse drug responses in ethnic groups.