The research of speech signal has been the significant progress recently. Regarding the convenience to the further analysis and application of speech signal, the elimination of meaningless periods in a given
speech signal is an indispensable pre-procedure in the research topics related to speech signal. However, the aforementioned is still not to be much solved accurately, noise and spikes especially. Accordingly, we propose a simple and effective method rather than requiring complex procedures. A multiresolution-based method is proposed, which is able to filter noise and spikes in speech signal automatically. Experimental results demonstrate the reliability and feasibility of the proposed method.