QuEChERS 為近年來所發展出新樣品前處理技術，利用液液微萃取以及固相吸附劑淨化兩個步驟完成萃取過程，可用於固態或液態樣品。若為固態樣品，則先將樣品粉碎達到均質的效果，再以乙腈進行液相液相微萃取，經由以吸附劑為無水硫酸鎂和一級二級胺之分散式固相萃取法達到淨化萃取之目的，最後進行儀器分析。整個過程主要以劇烈搖晃及離心等方式減少前處理所費時間，具有溶劑使用量少、價格便宜、所花費時間較短及操作簡單等優勢。目前已廣泛地應用於蔬果中多重農藥殘留之檢測，逐漸擴展至環境、食品以及生物分析等領域。本文將介紹其萃取過程，並介紹該技術於環境分析、食品安全以及生物樣品分析方面的應用。

QuEChERS, an acronym for Quick, Easy, Cheap, Effective, Rugged and Safe, is a new sample preparation method proposed in recent year. It can be used for solid and liquid samples analyses. After liquid extraction with acetonitrile,some of the extract was further purifi ed by anhydrous MgSO4 and primary secondary amine (PSA) sorbents. The cleanup solution was analyzed via proper instrument. This method was fi rst applied in the analysis of multi-residue pesticides. It is also applied to extract trace analytes in environmental, food, and biological matrices. This paper
will introduce the extraction procedure. The applications in the environmental analysis, food safety and biological analysis are also reviewed.