The present study analyzed the effects of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. ethanol extract on long-term(6-week) intoxication induced by intraperitoneal injections of 0.05 LD50 of cadmium chloride solution. The experiments were performedwith white laboratory mice. Two groups of mice were injected with ethanol extract of E. senticosus: 0.05 LD50 and 0.10 LD50. Cadmiumconcentrations were investigated in blood, kidney, liver, spleen, heart, and skeletal muscle by atomic absorption spectroscopy. Long-terminjections of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. ethanol extract combined with CdCl2 led to significant increase ofcadmium concentrations in the spleen, skeletal muscle, blood, kidney and liver of experimental mice. E. senticosus also decreased themitotic activity of liver cells induced by cadmium.