在醫療照護的過程中，醫療照護相關感染事件有其一定發生率，醫療照護相關感染事件只能盡量避免，但無法完全阻止其發生。其中血流感染通常具有較嚴重併發症及較高死亡率，容易造成病患的不必要傷害，延長住院天數，及增加醫院和健保醫療支出。各醫院的感染管制部門平時均會針對醫療照護相關感染進行持續性監測，必要時進行感染管制介入措施。醫療照護相關血流感染的發生有一些特定危險因子需要介入及控制，近年來發現導入及進行積極的組合式感染管制措施，有助於降低導管相關血流感染，本文對醫療照護相關血流感染及組合式感染管制措施之導入作進一步探討。

Health-associated infection events are known with fluctuant rate during the care in all health facilities. They can be prevented but never totally avoided. Healthcare-associated bloodstream infections result in a higher rate of morbidity and mortality compared with other infections, may also significantly increase the length of hospital stay and cost of hospital care. Surveillance and intervention of healthcare-associated infections are established and maintained by the infection control committee in healthcare facility. Recognition and prevention of the central line-associated bloodstream infections can be reduced by introduction of bundle intervention. We discuss the health-associated bloodstream infection and the effectiveness of bundle intervention.