一位23歲男性病人曾因鼻咽癌接受同步化學放射治療，四年後發生左眼眶腫脹和左眼臉下蠢，磁振造影發現左半邊臉有一15公分巨大腫瘤，手術切除後病理化驗證質為惡性骨肉瘤，核酸原位雜交也顯示腫瘤細胞為EB病毒陰性，放療後照射區域附近之腫瘤需考慮放療引發肉瘤之可能，即使潛伏期小於五年。

A 23-year-old man presented with left ptosis and periorbital swelling 4 years after concurrent chemoradiotherapy for his nasopharyngeal carcinoma. MRI revealed a 15 cm tumor in left hemiface. Craniofacial resection 01 the tumor was performed and showed a high-grade osteosarcoma. The tumor cells were negative for Epstein-Barr virus (EBV) by EBV-encoded small RNA in situ hybridization. Radiation-induced sarcoma should be considered in a previously irradiated patient even with relatively short latent period.