篇名 | Effects of Captopril on Melanin Formation in B16 cells |
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卷期 | 20:3 |
作者 | Heuy-Ling Chu 、 Bor-Sen Wang 、 Li-Chen Chang 、 Lee-Wen Chang 、 Pin-Der Duh |
頁次 | 668-673 |
關鍵字 | captopril 、 antityrosinase 、 reactive oxygen species 、 melanin formation 、 B16 melanoma cell 、 MEDLINE 、 Scopus 、 SCIE |
出刊日期 | 201209 |
The effect of captopril on melanin formation in B16 cells was investigated. In B16 intracellular model system, the effect of captopril on antityrosinase activity was found dose-dependent and correlated to its ability to suppress melanin formation. The copper chelation by captopril may in part be responsible for the inhibition of tyrosinase activity. Captopril also displayed a remarkable reducing ability and significantly inhibited ROS generation. Interestingly, captopril also significantly suppressed tyrosinase mRNA expression, as determined by reverse transcription-polymerase chain reaction (RT-PCR). Overall, the results showed that the protective effect of captopril makes it a potent inhibitor of melanin formation.