腮腺的多形性腺瘤是唾液腺中最常見的良性腫瘤，其中有非常少數會轉變為惡性腫瘤，而 轉變為惡性腫瘤中，轉化為上皮肉瘤是非常罕見的案例。上皮肉瘤顧名思義是同時具備上皮 癌，以及肉瘤的特徵。在過去文獻報導中個案數相當低，並且沒有一致的治療方針。手術切 除仍是目前治療的主要方式，而術後的放射線治療則可以增進其局部控制率。本篇病歷報告提 出一位 45 歲男性，在接受兩次切除右側腮腺多型性腺瘤之後，復發了多型性腺瘤合併上皮肉 瘤。我們給予手術表淺腮腺切除之後，術後執行了同步化學治療合併放射線治療，使用每周 cisplatin 的輸注以及 66 Gy 的放射線治療。病人追蹤 30 周，情況良好，沒有復發或轉移的現 象。

Pleomorphic adenoma of the parotid gland is the most common tumor of the salivary glands. Although very rare, this tumor can undergo malignant transformation, resulting in carcinosarcoma ex pleomorphic adenoma, which possesses the characteristics of both carcinoma and sarcoma. In the literature, the number of such cases is very low and the treatment outcomes are varied. Surgery remains the primary local treatment. Radiotherapy may be added to enhance local-regional control. Here, we present a 45-year-old male who underwent surgical removal of pleomorphic adenoma of the right parotid gland twice. He was eventually diagnosed with carcinosarcoma ex pleomorphic adenoma. Treatment consisted of superficial parotidectomy and adjuvant concurrent chemoradiation with weekly cisplatin and a radiation dose of 66 Gy. After 30 weeks of follow-up, no disease recurrence or distant metastasis was observed.