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藥物食品檢驗局調查研究年報
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| 篇名 | Endothelium-Dependent Higenamine-lnduced Aortic Relaxation in Isolated Rat Aorta |
|---|---|
| 卷期 | 15 |
| 作者 | Kai Kong Wong 、 Chi Fang Lo 、 Chi Ming Chen |
| 頁次 | 236-238 |
| 關鍵字 | TSCI |
| 出刊日期 | 199709 |
中文摘要
英文摘要
The pharmacological action of higenamine in isolated rat aorta was investigated. Although the beta-adrenoceptor antagonist propranolol {1 x 10_SM) completely blocked the beta-adrenoceptor agonist higenamine in inducing a positive chronotropic activity in isolated mouse atria, the higenamine-induced aortic relaxation was not completely antagonized by this concentration of propranolol. The present data also demonstrate that the higenamine-induced aortic relaxation was attenauted in the absence of endothelium. These findings suggest that the beta-adrenoceptor specificity to higenamine in aorta is different from chat of beta-1 in atria： moreover, the beta-adrenoceptors sensitive to higenamine are mainly located in the endothelial layer.