文章詳目資料
藥物食品檢驗局調查研究年報
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中文摘要
一般藥廠Cephalexin膠囊製劑之品質管制例行工作包括鑑別、力價 測定及溶離度試驗等項目，本實驗乃利用高效液相層析法來代替傳統的 微生物分析法來進行上述之品管工作。所使用層析管爲// Bondapak C18 ，移動相爲甲醇與1.25%冰醋酸（25 : 75)之混合液，内部對照標準品爲 Acetaminophen，檢測波長爲UV254 nm，於流速爲1.0 mL/min時，滯 留時間約8.5分鐘，應用此方法針對市售六家廠牌之Cephalexin膠囊製劑 做品質調查研究，包括含量均一度（Content uniformity)，溶離度試 驗（Dissolution test)及回收率（Recovery)等試驗，結果顯示其滯留 時間及回收率均不會受製劑中不同賦形劑之影響，此方法應用在 Cephalexin膠囊製劑之品質管制上，具有簡單，迅速及特異性等優點。
英文摘要
本卷期文章目次
- Determination of liquiritin，glycyrrhizin，hesperidin，cinnamic acid, cinnamaldehyde, honokiol and magnolol in the traditional Chinese medicinal preparation Wuu-Ji-San by high-performance liquid chromatography / Yuh-Chuang Lee、Cheng-Yu Huang、Kuo-Ching Wen、Tsi-Tee Suen
- Determination of higenamine in plasma and urine by high-performance liquid chromatography with electrochemical detection / Chi-Fang Lo、Chi-Ming Chen
- Analysis of forensic samples using precolumn derivatization with ( + )-l-(9-fluorenyl)ethyl chloroformate and liquid chromatography with fluorimetric detection / Yu-Pen Chen、Mei-Chich Hsu、Chun Sheng Chien
- Determination of the cysteine derivatives N-acetylcysteine， S-carboxymethylcysteine and methylcysteine in pharmaceuticals by high-performance liquid chromatography / F.Y. Tsai、C.J. Chen、C.S. Chien
- High-performance liquid chromatographic method for potency determination of cephalexin in commercial preparations and for stability studies / Mei-Chich Hsua、Yu-Shan Linb、Hsiou-Chuan Chung