Chronic kidney disease(CKD), a major public health problem, is a progressive loss in kidney function over a period of months or years. CKD is defined as the presence of kidney damage or decreased kidney function ( eGFR <60 mL/min/1.73 m2) for three or more months, irrespective of the cause. Chronic kidney disease can progress to end-stage kidney failure, which is a progressive, irreversible deterioration in renal function in which the body’s ability to maintain metabolic and fluid and electrolyte balance fails, resulting in uremia. Uremia may affect any part of the body. Including gastrointestinal system, cardiovascular system, neurologic system, integument system, and immune system. Treatment of uremia is now dominated by dialysis. Thus, how to delay dialysis initiation in CKD predialysis patients is a important issue. We report a case of a 59-year-old female patient with ESRD seeking TCM advice. The symptoms, serum creatinine and blood urea nitrogen(BUN) was improved after taking Chinese herbal formulae within 4 months. This approach seems to offer a effective alternative treatment for ESRD patients.