在本文綜述中說明玫瑰茄 (洛神花；Hibiscus sabdariffa, HS) 萃取物應用於人類 相關疾病，除對其生物活性、緩解作用等研究做一整理，也對此傳統藥用植物的生 化、藥理學的隨機臨床試驗 (randomized clinical trial; RCT)，並一併提供安全性和毒 性的研究整理。這一綜合的證據說明，HS 萃取物有可能作為多種人類疾病的有效緩 解物。本研究係檢視HS 萃取物對發炎反應的可能影響，藉由能否抑制包括一氧化氮 (nitric oxide, NO)、介白素6 (cytokine interleukin 6; IL-6)、腫瘤壞死因子-α (tumor necrosis factor; TNF-α) 三種發炎的生成。結果顯示，HS 萃取物能抑制細菌脂多醣 (Lipopolysaccharide; LPS) 所刺激的發炎IL-6 反應；同時，HS 萃取物對受測細胞並 無細胞毒性。因此，本研究結果，仍需通過臨床實驗驗證，以及更多數量的動物和 人類案例研究，為提供公共健康益處之有效建議。

In this comprehensive narrative literature review indicated that Hibiscus sabdariffa Flower Extract (HS) can effectively alleviate human-related diseases. The reviews also provided safety and toxicological information on this traditional medical through pharmacological randomized clinical trial (RCT) of phytochemistry and biochemistry. The comprehensive reviews also showed that HS extracts may serve as a relief for human disease. The objective of this study was to determine the effects of HS extract on lipopolysaccharide (LPS)-stimulated inflammation by suppressing three pro-inflammatory mediators, including nitric oxide (NO), cytokine interleukin 6 (IL-6) as well as tumor necrosis factor-α (TNF-α). The results showed that the HS extract exerted anti-inflammatory effect by suppressing inflammation, while cytotoxicity was not detected in the cells tested. Furthermore, the extract still needs to be verified by actual therapeutic practice and more high-quality animal and human studies to understand the effects of clinical trials. In practice, the purpose of the study hopes to enhance a wide range of public health benefits and well-being of humanity.