In order to make up for the shortcomings of the existing courses, a MOOC-based flipped classroom teaching mode is proposed to improve students’ interest in learning, autonomous learning ability, expressive ability, collaborative learning ability, practical and operational skills. The research results show that through the design and application research of the classroom teaching mode based on MOOC platform, it is found that the teaching mode has positive promotion effect in improving students’ interest in learning, cooperative consciousness, autonomous learning ability, practical and operational skills. The MOOC-based flip classroom teaching model can make up for the shortcomings of the traditional classroom teaching model, and truly reflects the “student-centered” education teaching concept. At the same time, the MOOC platform has high-quality curriculum resources, which promotes knowledge transfer and sharing worldwide, creating a lot of opportunities for teaching and learning in different disciplines and subjects. It can be seen that mixed learning can create situations, promote learning orientation, promote students’ cognition, enhance the meaning of constructivist learning, promote cooperative learning, and expand thinking development: mixed learning can promote the development of disciplines and specialty.