硫化氫存在於自然環境也常見於工業區。人們通常能夠聞到最低濃度氣味範圍為0.0005至百萬分之0.3ppm，硫化氫氣體會導致多種健康影響。硫化氫毒性的臨床表現包括視覺改變，嗅覺疲勞，噁心頭痛，呼吸窘迫或昏迷。本文闡述了硫化氫中毒的作用機轉，臨床表現和當前的治療對策。硫化氫為相對普遍，經常致命性且具獨特之職業暴露風險。根據統計，職場中發生致命性吸入性氣體暴露比例僅次於一氧化碳中毒。硫化氫中毒通常是零星案例且不可預測，臨床資訊僅來自於個案通報並缺乏暴露評估資料，且大多數急性中毒事件常可見因緊急搶救同伴而中毒，造成無法挽回的結果。若隨身或附近有個人呼吸防護裝備提供緊急使用，應可減少中毒事件之發生。

Hydrogen sulfide is colorless and odorless which exists in natural environments such as natural gas, volcanic gas, hot springs, crude oil. People can usually smell the lowest concentration in the range of 0.0005 to 0.3 portion per million. Exposure to high concentrations, such as 500 ppm, may cause acute pulmonary edema, knockdown effects and even death. Hydrogen sulfide gas can cause a variety of health effects. Clinical manifestations of toxicity include visual changes, olfactory fatigue, nausea, headache, respiratory distress or coma. This article describes the mechanism, clinical manifestations and current treatment strategies of hydrogen sulfide poisoning. Hydrogen sulfide is relatively common, often fatal and has a unique occupational exposure risk. According to statistics, the proportion of fatal inhalation gas exposure in the workplace is secondary to carbon monoxide poisoning. Hydrogen sulfide poisoning is usually sporadic and unpredictable. Clinical information only from case reports and lack of exposure assessment data. Most accidentally death are often accompanied with the emergency rescue of partners in acute poisoning events and resulting in irreversible results. If there is personal respiratory protective equipment for emergency use with or nearby, the incidence of poisoning may reduced.