目的：女性外部柏哲氏瘤是一種罕見的腫瘤，好發於白種人停後經後之婦女，此類疾病基本的治療方式是外科手術大範圍切除，但有些病患無法承受此種手術療法。我們報告二例女性外陰部柏德氏腫瘤之放射線治療結果。病例報告：二名高齡81歲的婦女罹患外陰部柏哲氏腫瘤，在本院接受電子合併光子射線之局部放射治療，其中一位（病患一）接受 40 Gy／20 次照射，另一位（病患二）接受50Gy／25次照射的體外放射線治療。病患在放射治療期間均併發局部腫脹、濕性脫皮、紅腫及疼痛之副作用，但病患對整個療程的耐受性良好。二名病患在治療後疾丙均達到完緩解，於原照野內無局部復發亦無其他臟器之惡性腫瘤產生。病患一在照射完10個月後在且門附近皮膚又發現新的柏哲氏腫瘤病灶，但在接受50 Gy（25次照射）放射線治療後獲得良好的局部控制，自第二次照射至今又追蹤達5個月。病患二追蹤至今已12個月，無局部復發之跡象。結論：放射線治療是對於大範圍或不適合外科手術之女性外陰部柏哲氏腫瘤的有效治療方法。

Background: Extramammary Paget’s disease (EMPD) of the vulva is an uncommon tumor which frequently affecting postmenopausal Caucasian women. Wide local excision is the recommended treatment, although this may not always be feasible. Wu report out experience in treating EMPD of the vulva by radiotherapy in two patients. Cases: Two 81-year-old women with EMPD in the vulvar region were treated using appositional electrons mixed with photon beams. One patient received 40 Gy in 20 fractions (patient 1), and the other one received 50 Gy in 25 fractions (patient 2).Both patients developed local swelling, focal moist desquamation, erythema and pain during the treatment course, but were tolerated well. Complete regression of EMPD was observed in both patients and neither local recurrences nor internal malignancies have been documented. Patient 1 developed new lesions over peri-anal region 10 months afterwards and was irradiated for another 50 Gy in 25 fractions with good local control. She was followed up for another 5 months with no evidence of disease. Patient 2 was followed up for 12 months without recurrence. Conclusion: Radiation therapy potentially could be a curative treatment in selected cases of EMPD disease affecting large areas of the vulva region or elderly and clinically inoperable patients.