1995年6月，臺灣新竹地區發生一件食物中毒事件，其中毒原因為食用雲紋蝦虎所致，患者夫婦一對，其中女患者較為嚴重，男患者較為輕微。患者中毒症狀為嘔吐、噁心、暈眩、口唇麻痺和呼吸困難。這些症狀與河魨毒中毒相似，因此將患者食用之殘餘三尾魚體依河魨毒之生物檢定法測其毒性，得知魚體毒性值範圍為個體9-156老鼠單位(MU)，肌肉4-24MU/g，頭部5-120 MU/g和內臟7-84 MU/g。最高毒性值為個體156MU，肌肉24MU/g，頭部 120MU/g和內臟84MU/g 。進一步為鑑定魚體之毒成分，乃將抽取液混合後經二氯甲烷脫脂、Diaflo YM-1膜超過濾和Bio-Gel P-2管柱層析法精製，部份精製之毒素則以電泳分析、高效能液態層析儀分析和氣相層析儀-質譜質分析，得知此魚體中之毒素含河魨毒和其關連物質脫氫河魨毒。綜合上述結果，得知本次食物中毒事件之原因物質乃為河魨毒。

A paralytic food poisoning incident due to ingestion of the goby Yongeichthys nebulosus occurred in Shinchu County, Taiwan , in June 1995. The couple poisoned had symptoms which were marked by severe numbness of the lips, vomiting and impaired breathing. Three uneaten fish specimens were dissected into muscle, head and viscera, and analyzed for toxicity. Using a tetrodotoxin bioassay the fish showed the highest toxicity of 24, 120 and 84 mouse units per gram (MU/g) in muscle, head and viscera tissues, respectively. The fish toxin was combined and purified by Diaflo YM-1 membrane ultrafiltration and Bio-Gel P-2 chromatography. The analyses of purified toxin by electrophoresis, high performance liquid chromatography and gas chromatography-mass spectroscopy indicated that the causative toxic agents were tetrodotoxin and a related substance anhydrotetrodotoxin.