氨基羥基胍的西佛鹼衍生物具有羥基胍葉效團，其結構與羥基脲，縮氨基硫脲和甲氨酰腺類似，實驗證明這類化合物多數具有比羥基脲及羥基胍更強的抗腫瘤和/或抗病毒活性。這類化合物的作用機制是抑制DNA合成的關鍵酶－核糖核苷酸還原酶。這篇論文研究並討論了54個這類化合物的紅外光譜及其在藥物分析中可能的應用。

Schiff bases of aminohydroxyguanidine were designed to contain the essential pharmacophore of hydroxyguanidine and have structural similarity to hydroxyurea, thiosemicarbazone and N-carbamyloxyurea. Most of these compounds have been shown to have antitumor and/ or antiviral activities more potent than hydroxyurea and hydroxyguanidine. Their mode of action is inhibition of ribonucleotide reductase which is the key enzyme in de novo DNA synthesis. Their infrared spectra (IR) are determined and discussed in this paper. Possible applications of the IR data in pharmaceutical analysis are presented.