The antibiograms of 45 human isolates and 87 animal isolates of Salmonellatyphimurium collected from 1990 to 1996 in Taiwan were investigated. Theantibiotics used were tetracycline (Te), sulfisoxazole (G), ampicillin (Am),chloramphenicol (C), streptomycin (S), trimethoprim-sulfamethoxazole (Sxt),kanamycin (K), gentamicin (Gm), norfloxacin (Nor) and cefoperazone (Cfp).Resistance to antibiotics for these Salmonella isolates was studied, and the resultsobtained for human and animal isolates were compared. It was found that theantibiograms for human and animal isolates are quite similar. The major resistant typefor these Salmonella strains is TeGAmSC. Both the human and animal isolates arehighly resistant to first-line antibiotics, such as tetracycline, sulfisoxazole, ampicillin,streptomycin of chloramphenicol; but are sensitive to fluoroquinolone antibiotics,such as norfloxacin and the third generation antibiotic of cephalosporin, such ascefoperazone and gentamicin. Between 93 % and 100 % of the local strains isinhibited by these antibiotics. Also, a significant fraction of these S. typhimuriumisolates are multidrug resistant strains. For example, 58.6% of the animal isolates and68.9% of the human isolates are multidrug-resistant. In conclusion, the antibiogramsfor human and animal isolates of S. typhimurium are similar. These results may beowing to the fact that Taiwan is geographically a small island and S. typhimuriumstrains are the common infective strains for human and domestic animals. Also, a highfraction of these strains was found to be drug resistant, which may be attributed to thefact that antibiotics are not strictly restricted for use in Taiwan.