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放射治療與腫瘤學

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篇名 Treatment Results of Polymorphic Reticulosis at Veterans General Hospital-Taipei
卷期 6:1
並列篇名 臺北榮民總醫院多形性網細胞增多症之治療成果
作者 夏錫生梁棉榮曾玉華許志宏李永賢季匡華陳光耀趙靜宜顏上惠
頁次 25-32
關鍵字 多形性網細胞增多症放射治療惡性淋巴腫瘤Polymorphic reticulosisRadiotherapyMalignant lymphomaTSCI
出刊日期 199903

中文摘要

     目的:回顧過去十五年(1982-1997)在臺北榮民總醫院多形性網細胞增多症(現已改稱為中央血管增生型 T- 細胞淋巴症)之治療成果。材料與方法:自 1982 年 12 月至1997 年 12 月共有 40 例罹患多形性網細胞增多症之病患在臺北榮民總醫院就診, 其 35名為男性,5 名為女性,其年齡介於 14 至 78 歲之間,追蹤期間為 1 至 172 個月。經整理每一病患之病歷, 以追溯其病史,臨床及生化血液檢驗、X 光檢查及治療方式。 其中 5名病患只接受化學治療, 19 名病患接受放射治療,另 16 名病患接受合併放射、化學或外科治療。 結果:全體 40 名病患無疾病 5 年存活率為 35 %,單接受放射治療之病患,其5 年無疾病存活率為 57 %,接受放射治療合併化學治療或外科治療者為 19 %,若扣除放射治療合併化學治療者則僅剩 8 %。 患灶數目( =1 ),身體狀況( K scale>70 ),治療方式無手術治療為有統計意義之較佳預後因子。 40 例病患有 23 例因病死亡,其中有 5例遠端轉移,4 例局部復發,其他 14 例有包括敗血症、肺炎及出血有關之病症而死亡,因病歷記載未詳盡,無法判斷上述 14 例死因是否與原發病灶有關。 15 例有接受過化療者僅有 2 例復發,25 例無接受化療者有 7 例復發。 結論:多形性網細胞增多症,局部放射治療之結果良好,化學治療對防止復發有利。病灶數目只有一處,身體狀態 K scale 大於 70分,未曾接受手術者為較佳的預後因子。

英文摘要

     Purpose:Retrospectively review the treatment results of polymorphicretculosis ( now called angiocentric T-cell lymphoma ) patients at Veateranseneral Hospital-Taipei over the past fifteen years ( 1982-1997 ).Materials andMethods: From December 1982 to December 1997, there were 40 patients diagnosedof polymorphic reticulosis at Veterans General Hospital-Taipei. There were 35male patients and 5 female patients. The age of the patients ranged from 14 to78 years old. The follow-up period ranged from 1 to 172 months. Medicalhistories, laboratory and X-ray examinations and modalities of treatment frommedical records of each patient were reviewed. Five patients receivedchemotherapy alone, 19 patients received radiotherapy alone and 16 patientsreceived radiotherapy combined with chemotherapy or surgery. Results:The 5-yeardisease-free survival rate of all patients was 35 %.The 5-year disease-freesurvival rate for patients receiving radiotherapy alone was 57 %. It was 19 %for patients treated with radiotherapy plus surgery, chemotherapy or both; and 8% only for patients received surgery combined with other treatments. Number ofinvolved sites ( =1 ), Karnofsky scale ( >70 ), non-surgery treatment arepositive statistical prognostic factors. There were 23 patients died and 9 ofthem have evidence of disease progression ( 5 cases of distant metastasis and 4cases of locoregional recurrence ). There were 2 patients relapsed in 15patients who received chemotherapy, and there were 7 patients relapsed in 25patients who without chemotherapy. Conclusion: Polymorphic reticulosis hadexcellent local control rate by radiotherapy. Chemotherapy may be benefit forprevention of distant metastasis and local recurrence. Number of involved site( s ), good Karnofsky scale, and non-surgical treatment are associated betterprognosis.

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