目的：回顧性分析以放射治療或合併化學治療之方式治療可切除之頭頸部腫瘤的可行性、治療副作用及存活率。材料與方法：三十位診斷為可切除之頭頸部腫瘤病人接受根治性放射治療或合併化學治療。一位病人為第一期，四位第二期，三位第三期，二十二位第四期疾病。 放射治療為一日一次或一日兩次，總劑量為 68-74Gy。 化學治療使用 CDDP 與5-FU， 包括兩次放射治療中的合併治療， 與兩次放射治療後的治療。 以 Kaplan-Meiermethod 分析存活率，以 long-rank test 分析預後因子。結果：追蹤時間之中位數為 50.8個月。 四年整體整活率、無病存活率及局部控制率分別為 55.7 ％、64.9 ％及 75.8 ％。治療相關的副作屬可忍受。 T1/T2 腫瘤的病人在統計上具有意義的較佳局部控制率（p=0.03 ）。 治療結束後的核磁共振或電腦斷層檢查中若有殘存疾病的病人，具統計上有意義的較差整體存活率（ p=0.05 ）、 無病存活率（ p=0.009 ）及局部無再發存活率（p=0.001 ）。 結論：放射治療或合併化學治療之方式治療可切除之頭頸部腫瘤可考慮為根除手術外的一種選擇。它具有可接受的治療相關副作用及存活率。治療結束後的核磁共振或電腦斷層檢查中若有殘存疾病的病人，應接受進一步探查與治療。

　　　　　Purpose：To retrospectively analyze the feasibility, toxicity andoutcome of definitive radiotherapy with or without chemotherapy for patientswith resectable head and neck cancers. Materials and Methods： Thirty patientswith resectable head and neck cancers were treated with definitive split-courseradiotherapy with or without concurrent chemotherapy. One patient had stagel, 4Ⅰ stage, Ⅱ 3 stage Ⅲ and 22 stage Ⅳ diseases. Radiotherapy was given oncedaily or twice daily with total dose of 68-74 Gy. Chemotherapy included 2 cycleswith CDDP+/-5FU during radiotherapy, and 2 cycles with CDDP+5FU after radiationtreatment. Survival outcome was calculated by the Kaplan-Meier method.Prognostic factors were determined by log-rank test. Results： The medialfollow-up time was 50.8 months. The 4-year overall survival, disease-freesurvival and locoregional control rates were 55.7 ％,64.9 ％ and 75.8 ％,respectively. Treatment-related toxicities were tolerable. T1/T2 diseases wereassociated with better locoregional control （ p=0.03 ）. The presence ofresidual disease on post-treatment MRI or CT was the prognostic factor foroverall survival （ p=0.05 ）, disease-free survival （ p=0.009 ） andlocoregional recurrence-free survival （ p=0.0001 ）. Conclusion： Definitiveradiotherapy with or without chemotherapy can be an alternative to radicalsurgery for patients with resectable head and neck cancers, with acceptabletoxicity and outcome. The presence of residual disease on post-treatment imagingstudies demands further investigation and possibly salvage treatment.