篇名 | 子宮頸癌高劑量率與低劑量率體腔內近接治療之現況與比較 |
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卷期 | 4:3 |
並列篇名 | Current Status and Comparison of High-Dose-Rate (HDR) vs. Low-Dose-Rate (LDR) Intracavitary Brachytherapy in Treatment of Cervical Carcinoma |
作者 | 王重榮 、 梁雲 、 陳惠君 、 孫立民 、 方富民 |
頁次 | 237-241 |
關鍵字 | 體腔內近接治療 、 高劑量率 、 子宮頸癌 、 Intracavitary brachytherapy 、 High-dose-rate 、 Cervical carcinoma 、 TSCI |
出刊日期 | 199709 |
子宮頸癌體腔內近接治療的技術與趨勢, 在過去的十年有極顯著的轉變:高劑量率( HDR )技術正逐漸的取代過去使用近半世紀的低劑量率( LDR )技術。臨床的報告顯示,HDR 的結果與 LDR 相當、或比 LDR 略好,更重要的是嚴重的併發症有明顯的減少。這其中必須歸因於 HDR 射源的改進與電子機械設備的現代化, 以及 HDR 適當的分次治療。HDR 與 LDR 的隨機比較、最適當分次原則、直腸併發症的減少是 HDR 將來重要的議題。
Over the past one decade, there was a significant reverse in clinicalattitude to the high-dose-rate (HDR) intracavitary brachytherapy for treatmentof cervical carcinoma. Cumulative data from both meta-analysis and a fewavailable randomized studies have shown that results of HDR were comparablewith, or slightly superior to, that of the existing low-dose-rate (LDR) results.The improvement of treatment results, parallel with a significant reduction ofsevere rectal complication rate (Grade 3 and 4), has been attributed mainly tothe improved physical/mechanical characteristics of HDR facility and the use ofappropriately fractionated treatment. Prospective randominzed comparison of HDRvs. LDR, optimal dose-fractionation study, and prediction/prevention of rectalcomplication are the three central issues of HDR in the future.