目的：探討放射線治療前EB病毒VCA抗體指數和鼻咽癌患者臨床表徵的關係，並分析抗體指數高低與預後的關係。 材料及方法：自 1991 年 4 月至 1995 年 9 月， 有 101位患者於治療前一個月內曾接受 EB 病毒 VCA 抗體的測試。 我們作抗體幾何平均指數及血清陽性率對性別、年齡、WHO 組織學形態和臨床分期等臨床因素關係的分析，並分析鼻咽癌之預後因子及 EB 病毒 VCA 抗體值與預後的關係。 結果：101 位患者 VCA 之 lgA 及 lgG抗體的幾何平均指數分別為 102 及 1316， 而血清陽性率分別為 87.00% 及 91.70%。VCA-lgA 幾何平均指數在女性明顯較高 (p=0.040)，lgA 血清陽性率則於年長及疾病期別高的患者有明顯偏高 (p=0.047 及 0.015)。而 VCA-lgG 抗體和這些臨床表徵並無密切關係。鼻咽癌預後和性別及疾病期別有關。 而 VCA 抗體陽性與否和抗體高低皆與預後無關。結論： 雖然治療前的 VCA 抗體幾何平均指數有隨期別增加而增加的趨勢， 但無明顯差異。 而VCA-lgA 血清陽性率和年齡、T 期別及 AJCC 分期有相關性。此外，VCA 抗體值並不可為推測預後的因素。[ 放射治療與腫瘤學 1997;4:101-107]

　　　　　Purpose: To assess the relationship between the pre-R/T EBV VCA titersand the characteristics of the patients with NPC and to anlayze the prognosticvalue of the tiers Materials and Methods: From April 1991 to September 1995, 101patients with nasopharyngeal carcinoma who received the examination of EBV VCAtiters before radiotherapy were reviewed. We analyzed the correlation betweentiters and clinical characteristics, including genders, age, WHO histologictypes and stages. We also tried to find the role of these tiers in predictingprognosis. Results: We found that the geometric mean titers of EBV VCA-IgA ofthese 101 patients were 102 and 1136 and the seropositive rates were 87% and91.7%, respectively. the GMTs of IgA and IgG trended to be increased in advancedstages, but no significant difference in statistics. There is no significantdifference of GMTs in other clinical features, except IgA titer in sex. Theseropositive rates were higher in elders, higher T stage and advanced stage. Therole in predicting prognosis was not found. Conclusions: The pre-treatment EBVVCA GMTs increased in advanced stages, but the difference was not significantand they were not proper factors in predicting prognosis. [Therapeut RadiolOncol 1997; 4:101-107]