目的：研究各項有關頭頸部淋巴結外非何杰金氏淋巴癌之預後因子。
材料與方法：自 1984 年 6 月至 1992 年 4 月，共有 22 位罹患淋巴結外非何杰金氏淋巴癌之病患於本科接受放射線治療。 其中男性 16 位，女性 6 位，年齡介於 14 至 79 歲之間，追蹤期間為 6 至 133 個月。使用之機器為鈷六十遠隔治療，6 或 10 百萬伏特之直線加速器，放射治療總劑量為 2998 至 7001 cGy。 經由回溯整理其治療記錄及病歷來研究各項預後因子。
結果：本文分析相關之預後因子，發現腫瘤之分期 (Ann Arbor stage) 為影響預後之主要因素。整體之五年存活率為 57%。治療失敗包括有八名病患發生遠端復發，三名病患在原發部位復發，以及一名病患在鄰近之淋巴結復發。主要死因為遠端復發。腫瘤分期第一期之五年存活期可達到 88%，第二、三、四期之五年存活期則分別為 53%，0%，0%。放射治療之急性副作用以黏膜及唾液腺為主。
結論：早期頭頸部淋巴結外非何杰金氏淋巴癌之治療以放射線治療可以獲得相當不錯的結果。 至於其僚預後因子之分析則有待未來更多資料收集。[放射治療與腫瘤學 1997;4:77-84]

Purpose:To evaluate a variety of disease- and treatment-related variables that influ-ence the prognosis of extranodal non-Hodgkin's lymphoma of the head and neck.
Materials and Methods: From June 1984 to April 1992, 22 patients with extranodal non-Hodgkin's lymphoma of the head and neck area had received radiotherapy at Taichung Veterans General Hospital. There were 16 males and 6 females between 14 and 79 years of age. The follow-up period ranged from 6 to 133 months. All patients were treated with Co-60 teletherapy machine, 6 MV or 10 MV linear accelerator. The radiation dose ranged from 2998 to 7001 cGy (mean: 4609 cGy). Prognostic factors such as the Ann Arbor stage, pathologic grading, number of involved sites, Waldeyer's ring involvement, age, sex, extent of radiation field, radiation dose, and LDH level were anaIyzed by retrospective review of the medical records.
Results: The most common acute radiation reactions occurred at mucous membrane and salivary gland. The overall 5-year disease-specific survival rate was 57%. Treatment failures included distant relapse (8 patients), relapse in primary site (3 patients) and regional LN (1patient). The major cause of death was distant relapse. The Ann Arbor stage was the only significant prognostic factor in this study. The 5-year disease-specific survial was excellent for stage I disease (88%) and the survival rates for stage II, III, and IV were 53%, 0%, and 0%, respectively.
Conclusion: Non-Hodgkin's lymphoma arising from extranodal sites in the head and neck area was uncommon. The most significant prognostic factor was extent of the disease (Ann Arbor stage). Proper management of patients with early stage non-Hodgkin's lymphoma of the head and neck area remains controversial. However, excellent survival for stage I non-Hodgkin's lymphoma in the head and neck arising from extranodal sites was achievable by radiation therapy in this study. [Therapeut Radiol Oncol 1997; 4:77-84]