目的：低惡性度腦瘤的術後放射治療，尤其是星狀細胞瘤的處理是個爭議性的課題，本研究探討低惡性度星狀細胞腦瘤的預後因子並對其治療做一個回顧與評估。材料與方法：1979 年至 1988 年間， 共有 46 位低惡性度星狀細胞腦瘤的成人患者在林口長庚醫院完成術後放射治療。他們年紀從 15 歲至 63 歲，中間值是 32 歲。有 25 位男性，21 位女性。 根據 Kernohan 的病理分期標準，這些病人有 10 位患者屬第一級，36 位屬第二級。其中 11 位病人接受腫瘤完全切除術，17 位接受部份切除術，而另 18 位只接受切片檢查，並沒有切除腫瘤。開刀後，46 位患者都有很好的行動指標 (Performance status)。每位病人都接受 Co-60 或百萬電子伏特以上的光子射線治療。 治療劑量從 44-66 Gy 不等，劑量的中間值是 60 Gy。沒有患者在一開始便接受化學治療。結果：五年的存活率是 49%，女性比男性患者有較好的存活率 (54% vs. 24%, P=0.015)； 年齡小於或等於 30 歲者比年紀大的病人有較好的治療結果 (47% vs. 30%, P=0.035)； 病理分期屬第一級者比第二級者預後較好 (69% vs. 30%, P=0.04)；開刀範圍的大小並不影嚮預後，但有開刀切除者比只做切片者有較好的五年存活率 (44% vs. 32%, P=0.05)；術後放射治療劑量的高低對預後並無實質的影響。結論：根據我們治療的結果發現低惡性度星狀細胞瘤病人接受術後放射治療的結果並不佳，其中更以 Kernohan 第二級病人的表現較差。因此尋求更積極有效的治療方式應是優先考量的課題。

　　　　　Purpose:It got no consensus about the therapy of low grade glioma,especially for the low grade astrocytoma. We have retrospectively reviewed theresults of radiotherapy for low grade astrocytoma, and define the role ofpostoperative radiotherapy in the treatment of low grade astrocytoma. Materialsand Methods:From 1979 to 1988, 46 adult patients with low grade astrocytomareceived postoperative radiotherapy in Chang Gung Memorial Hospital --LinkouMedical Center. The median age of these patients was 32 years old with the rangefrom 15 to 63. There were 25 male and 21 female. According to the Kernohan'sgrading system, 10 patients' tumors belonged to grade 1 and the others belongedto grade 2. Eleven patients received total removal of tumors, 17 patientsreceived subtotal excision of tumors, and 18 patients received biopsy only. Allpatients had good performance status (Karnofsky scale>70) after operation. Forradiotherapy, the median total dose was 6000 cGy on each patient, ranging from4400 to 6600 cGy. No patient received chemotherapy at the beginning. Result:Theoverall 5 year survival was 79%. Female had better survival than male (54% vs24%, p=0.015). Younger patients had better results than older patients (47% vs30%, p=0.04). Patients with grade Ⅰ tumors had better survival than patientswith grade Ⅱ tumors (69% vs 30%. p=0.04). Patients received excision surgeryhad better survival rate (44% vs 32%, p=0.05), but the extent of surgery did notmake the difference. Total radiation dose did not significantly change thesurvival result. Discussion:The low grade astrocytoma patients showed poorsurvival rate after radiotherapy, especially for patients with group Ⅱ tumor.To properly treat patients with low-grade astrocytoma is a more important issuethan to consider the incidence of radiation complication.