結構基因體研究的目的是要以實驗及理論計算的方法來決蛋白質的三度空間結構。蛋白質的結構資訊不僅對功能的註解有用，對新藥的研發也很重要，另一個目標是提供每一個蛋白質家族至少有一個代表性的結構。如何在眾多的候選者選出目標來決結構是非常重要的，因此利用生物資訊的方法來分析序列及結構的資料，以提供目標蛋白的選擇就成了結構基因體計畫的第一步。我們可以藉由比較已知的資料庫資料，預測及分析目標蛋白，來幫助結構學家選擇目標，並提供一個溝通及協調的平臺。

The structural genomics project aims at determination of the 3D structure of all proteins experimentally and theoretically. Structural information of a protein is valuable in functional annotation and powerful in new drug-discovery. Another goal is to provide at least a representative structure for each protein family. Sequence and structure data will be combined using bioinformatics methods (a) to compare with the known data in the database, (b) to predict and analyze targets, (c) to help target selection, (d) and to provide a platform to communicate and coordinate.