背景：特雷托氏是一種複雜的經精神病學方面的病症。誤性腦部掃描如鎝-99mTc-HMPAO腦部單光子射出斷層掃描已被廣泛使用於評估此類的病患。但是，鎝-99mTc-ECD腦部單生子射出斷層掃描對於兒童患有特雷托氏症的評估價值。
方法：本先期研究包含了17位未曾接受過治療的兒童特雷托氏症病患和7位正常對照組來托受鎝-99mTc-ECD腦部單光子射出斷層掃描。如有過腦耜外傷、癲癇、腦炎或腦膜炎情形之病患對照組就不被包括在本研究的範圍之內。
結果：在17位特雷托氏的兒童當中，16位(94.1%)發現鎝-99mTc-ECD腦部單光子射出斷層掃描中有腦內血流灌注缺的鎝-99mTc-ECD腦部單光子射山斷層掃描結果為正常。
結論：本先期研結果顯示鎝-99mTc-ECD腦部單光子射山斷層掃描在評估患有特雷托氏病的病患方面也是一個很有用的腦部功能性檢查。

Gilles de la Tourette's syndrome (GTS) is a complex enurposychiatric disorder. Functional neuroimaging technique such as 99mTc-hexamethylpropylene amine oxime (HMPAO)brain SPECT has been used widey to evaluate the patients with GTS; however, the feasibility of 99mTc-ethyl cysteninate dimmer (ECD) brain SPECT in evaluation of patients with GTS has not been reported, especially in children. The aim of this preliminary study was to evaluate the potential usefulness of 99mTc-ECD brain SPECT in detecting brain perfusion abnormalities in children with GTS.
Methods: A group of 7 normal control subjects and 17 unmedicated GTS children (15 boys and 2 girls ranging in age from 4 to 11 years) underwent a brain SPECT study with 99mTc-ECD. Those with a known underlying history of brain trauma, epilepsy or encephalitis/meningitis were excluded.
Results: 16 of 17 (94.1%) of the GTS children had lesions characterized by decreased brain perfusion on 99mTc-ECD brain SPECT scan. The left hemisphere was more frequently involved and major perfusion abnormalities were found in the frontal lobe, temporal lobe, parietal lobe and basetal lobe and basal ganglia. In contrast, all 7 normal controls (100.0%) had negative results of 99mTc-ECD brain SPECT scan.
Conclusion: Our preliminary study showed the 99mTc-ECD brain SPECT scan may provide a useful functional neuroimaging technique in the evaluation of children with GTS.