篇名 | Pharmacodynamic Evaluation of Terminalia bellerica for Its Antihypertensive Effect |
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卷期 | 16:3 |
並列篇名 | Terminalia bellerica對於抗高血壓功效之藥物動力學評估 |
作者 | Khan, Arif-ullah 、 Gilani, Anwarul Hassan |
頁次 | 6-14 |
關鍵字 | Terminalia bellerica 、 Antihypertensive 、 Ca++ antagonist 、 抗高血壓 、 抗Ca++ 、 MEDLINE 、 Scopus 、 SCIE |
出刊日期 | 200806 |
Terminalia bellerica has been used as a folk medicine in a variety of ailments including hypertension. Our aim was to investigate the possible mechanism of its blood pressure (BP)-lowering effect. The crude extract of Terminalia bellerica fruit (Tb.Cr) which tested positive for flavonoids, sterols and tannins induced a dose-dependent (10-100 mg/kg) fall in the arterial BP of rats under anaesthesia. In isolated guinea-pig atria, Tb.Cr inhibited the force and rate of atrial contractions. In rabbit thoracic aorta, Tb.Cr relaxed the phenylephrine (PE, 1 μM) and K+ (80 mM)-induced contractions as well as suppressed the PE (1 μM) control peaks in the Ca++-free medium, similar to that caused by verapamil. The vasodilator effect of Tb.Cr was endothelium-independent as it was not opposed by Nω-nitro-L-arginine methyl ester in endothelium-intact rat aortic preparations and it occurred at the similar concentration in the endothelium-denuded tissues. These results indicate that Terminalia bellerica lowers BP through Ca++ antagonist mechanism and thus provides a sound mechanistic background for its medicinal use in hypertension.