氣管腺樣囊狀癌為一種罕見疾病，其治療是以手術為主。我們報告一位氣管腺樣囊狀癌的40 歲男性病患，經手術、同步化學放射治療（總劑量為 64.8 Gy，以 36 分次給予，同時給予每週Cisplatin 30 mg/m2）及輔助化學治療（每月給予5-Fluorouracil 及Cisplatin）後，短期內卻發現有局部復發及肺部轉移的情形。經肺轉移切除後，開始了以 Etoposide 及 cisplatin 為基礎的搶救性化學療法。但是經過 3 次搶救性化學療法後，疾病依舊持續進展。值得注意的是，稍後卻發現腫瘤對以口服 Etoposide 及 Cisplatin 為基礎的節拍式化學治療有良好的反應，且負作用亦不大。在這篇報告中，我們發現對於放射線及化學治療反應不佳的轉移性氣管腺樣囊狀癌，節拍式化學治療或許是一個選擇。

Adenoid cystic carcinoma (ACC) of the trachea is a rare disease and primarily treated with surgery. Here we report a 40 years-old male patient with ACC of the trachea.
He was initially treated with surgery, concurrent chemoradiotherapy (delivered with a total dose of 64.8 Gy in 36 fractions concurrently with weekly cisplatin 30 mg/m2) and adjuvant chemotherapy (monthly 5- fluorouracil and cisplatin). However, local recurrence and lung metastasis developed within a short period. After pulmonary metastatectomy,salvage chemotherapy with etoposide and cisplatin for 3 cycles were given but the
disease kept progressing. Intriguingly, metronomic chemotherapy with oral etoposide and cyclophosphamide showed a good tumor response with minimal adverse effect. We reported that metronomic chemotherapy might be an option for the metastatic ACC of the trachea refractory to radiation and chemotherapy.