測量超大質量(m > 1 MDa) 的生物粒子的質量是目前質譜學研究的一項挑戰。利用新近發展的軟離子化方法－雷射誘導聲波脫附法，結合四極式離子阱或圓柱型離子阱質譜儀及電荷感應偵測器，我們成功地測量了一些完整的生物粒子(包括病毒、細菌與動物細胞等) 的質量，其範圍涵蓋1 ￥ 108 Da－1 ￥ 1014 Da，粒徑大小約為100 nm－10 mm。有別於傳統的質譜學，筆者進行的是單個粒子的質量量測。

Measuring masses of ultrahigh-mass bioparticles (m > 1 MDa) has been a challenge in the field of mass spectrometry. Combining the techniques of laser-induced acoustic desorption, charge-sensitive detection, and quadrupole ion traps as the mass analyzer, we have successfully measured the masses of intact bioparticles such as viruses, bacteria, and cells in the gas phase for the first time. These particles have sizes ranging from ~100 nm to ~10 mm, with masses spanning up to 6 orders of magnitude (108－1014 Da). Different from conventional mass spectrometry, we measured the masses of these bioparticles individually.