本研究旨在了解底渣處理業勞工血液多氯戴奧辛/.喃 (Polychlorinated dibenzo-p-dioxins and dibenzofurans, PCDD/Fs) 濃度與作業環境空氣暴露及勞工健康指標之相關性。選取國內一座底渣處理廠共36位勞工為研究對象，進行血液中PCDD/Fs濃度及生化荷爾蒙指標分析，同時輔以健康、飲食問卷及時間-活動模式調查。亦選取廠內底渣儲存區與生產線區共2處為採樣點，進行作業環境空氣中PCDD/Fs含量採樣分析。結果顯示，底渣儲存區及生產線區空氣中PCDD/Fs總濃度分別為0.252及0.350 pg I-TEQ/Nm3，固相戴奧辛濃度均高於氣相 (88.4 % v.s 11.4%)，且均以OCDD、1,2,3,4,6,7,8-HpCDD、1,2,3,4,6,7,8-HpCDF及OCDF為主要污染物。依36位勞工血清中PCDD/Fs濃度之中位數 (8.83 pg WHO98-TEQDF/g lipid) 區分為高、低濃度組後，高濃度組血清中PCDD/Fs濃度顯著高於低濃度組，分別為12.3 及7.20 pg WHO98-TEQDF/g lipid。兩組在17 種PCDD/Fs同源物之分布均以OCDD、1,2,3,4,6,7,8-HpCDD、1,2,3,4,6,7,8-HpCDF為主要污染物，並與作業環境空氣分布相似。再與附近焚化廠周邊背景居民比較，發現兩組勞工血液中戴奧辛之1,2,3,4,6,7,8-HpCDF之貢獻均高於背景居民，與空氣中PCDD/Fs同源物分布一致，顯示廠內勞工可能由空氣途徑暴露到戴奧辛。高、低濃度組勞工之生化及荷爾蒙含量異常率均未達顯著差異。勞工血液中PCDD/Fs濃度之影響因子解析顯示，年齡與勞工總年資為勞工血液中PCDD/Fs濃度之主要影響因子。底渣處理廠勞工之PCDD/Fs 暴露可能和作業環境有關，目前勞工血中PCDD/Fs濃度雖低，但因PCDD/Fs為長期累積性物質，仍宜要求勞工佩戴適當之呼吸防護具，以降低職場暴露，確保勞工之健康。

The objectives of this study were to investigate the health effects of polychlorinated dibenzo-pdioxins and dibenzofurans (PCDD/Fs) exposure and to investigate associations between environmental exposure in bottom ash treatment plants and the serum PCDD/Fs of workers. For this study, 36
workers were recruited from a bottom ash treatment plant, and their serum PCDD/Fs levels, blood biochemistry, and hormones examination indices were determined. At the same time, their personal exposure data and time activity pattern were collected with questionnaires. Levels of airborne PCDD/Fs in the bottom ash storage area and treatment area were measured at 0.252 and 0.350 pg I-TEQ/Nm3, respectively. Particle bound PCDD/Fs levels were higher than gaseous PCDD/Fs in the bottom ash storage and treatment areas. OCDD, 1,2,3,4,6,7,8-HpCDD, 1,2,3,4,6,7,8-HpCDF, and OCDF were the main congeners. The 36 workers were sorted into high and low level groups based on their mean serum PCDD/Fs level. The serum PCDD/Fs levels were 12.3 and 7.20 pg WHO98-TEQDF/g lipid in the high and low level groups respectively. OCDD, 1,2,3,4,6,7,8-HpCDD, 1,2,3,4,6,7,8-HpCDF were the major congeners in the high-level group, and the congener pattern was the same as for the airborne PCDD/Fs. There were no statistically significant differences in the blood biochemistry and hormone examinations between the two groups. The regression data showed that serum PCDD/Fs were highly correlated with seniority and age. Thus, the senior workers may have been exposed to higher levels of PCDD/Fs emitted from bottom ash treatment processes. The usage of personal protective measures was suggested to reduce exposure to PCDD/Fs.