背景:惡性腫瘤由於細胞分裂增殖過述，血管之增生趕不上細胞成長途率，因比較大之腫瘤其內部常因血液及氧氣供應不足而有相當比例之缺氧或壞死細胞。鎝-99m-HL91被發現不論是在試管或活體中，對於缺氧的組織均比非缺氧的組織有較高親和力。本研究探討國內自行研發鎝-99m-HL叫做為腫瘤造影劑的可行性，並與鉈-201進行比較。

方法:HL91標幟小瓶與鉈-201由核能研究所提供O小瓶加入鎝-99m-過鎝酸鈉完成鎝-99m-HL91標幟，以靜脈注射進入 種植KHT肉瘤的C3H小白鼠體內。注射後1小時、1.5小時及2小時進行全身加馬攝影，並且計算腫瘤/正常組織攝取比值。之後將老鼠犧牲，進行自動放射照像。鉈-201研究平行進行以供比對。

結果:鎝-99m-HL91在腫瘤部位有攝取增加的現象;1小時、1.5小時及2小時的鎝-99m-HL91腫瘤/正常組織攝取比值分 別為2.986、2.351及1.872。鉈-201的影像表現類似的放射活性分佈;1小時、1.5小時及2小時的鉈-201腫瘤/正常組織攝 取比值分別為1.457、1.709及1.781。

結論:初步結果顯示核能研究所製備的鉈-99m-HL則是一種有潛力的種瘤造影劑。

Background: Many malignant tumors are characterized by perfusion heterogeneity due to its proliferation more rapid than the vascularity， which results in tumor regions that are acutely or chronically hypoxia. 99mTc_ HL91 is an amine oxime core radioligand that has shown oxygen dependent passive in vivo and in vitro binding with higher binding under hypoxic conditions than under non-hypoxic conditions. This study evaluated the domestic preparation of 99mTc_H L91 for its feasibility as a tumor imaging agent， and compared the results with叫TI-TICI ('TI)

Methods: The lyophilized kits of HL91 and 2oITI_TICI were produced by INER. Following reconstitution of the kit with 99mTc-pertechnetate， 99mTc-HL91 was injected intravenously into C3H mice bearing KHT sarcoma xenografts. Whole-body scans were performed at 1 h， 1.5 hand 2 h post-injection. The ratios of tumor-to-normal tissue background (TIN) were measured. After imaging study， the mice were sacrificed and underwent autoradiography. Parallel studies with叫TI were performed for comparison.

Results: There was increased uptake of 99mTc-HL91 at tumor regions. The TilI ratios of 99mTc-HL91 measured at 1 h， 1.5 hand 2 h were 2.986， 2.351 and 1.872， respectively. The images of叫TI showed similar distribu-tion of activity. The TilI ratios of'TI at 1 h， 1.5 hand 2 h were 1.457， 1.709 and 1.781， respectively.
Conclusion: The preliminary result suggested that 99mTc-HL91 produced by IIIER is a potential agent for tumor imaging.