本研究探討不同萃取溶劑及連續式超臨界反溶劑沉澱法之操作參數對花生膜萃取物微粒化之影響。花生
膜分別以甲醇、乙醇、丙酮、乙酸乙酯及異丙醇製備萃取液後，直接以超臨界反溶劑沉澱法處理，皆可成功製備微粒；微粒之總酚類化合物含量及DPPH自由基清除能力，以丙酮組之64.48及57.82%最佳，至於微粒產率則以甲醇組之6.16 mg/mL最高。於沉澱溫度35-55℃ 、沉澱壓力90-150 bar、溶液流速0.25-1.00 mL/min及二氧化碳流速3.5-11.5 mL/min之條件下，乙醇萃取之花生膜萃取液皆可透過超臨界反溶劑沉澱法成功獲得乾燥之微粒，且在上述參數操作範圍內其總酚類化合物含量介於53-58%。本研究並以五公升沉澱槽之中間工廠級設備進行製程放大，成功製得花生膜萃取物微粒，顯示溶劑萃取與超臨界反溶劑沉澱結合之程序應具量產應用之可行性。

The effect of various solvents and operating parameters through continuous supercritical antisolvent precipitation (SASP) process on the micronization of peanut skin extracts (PSE) were investigated in this
study. Methanol, ethanol, acetone, ethyl acetate and isopropanol were used to extract peanut skin separately and the microparticles of various PSE could be obtained by SASP processing successfully. Using acetone
as extraction and micronization solvent, the total phenolic compounds (TPC) content and 1, 1-diphenyl-2- picrylpydrazyl (DPPH) scavenging activity of PSE microparticles were 64.48 and 57.82%, respectively, and
were the best among all solvents. Using methanol as extraction and micronization solvent, the production yields of PSE microparticles was 6.16 mg/mL and was the best among all solvents. Ethanol PSE microparticles
can be produced by SASP process successfully by using precipitation temperature 35-55℃ , precipitation pressure 90-150 bar, PSE solvent flow rate 0.25-1.00 mL/min, and carbon dioxide flow rate 3.5-11.5 mL/min.
The TPC content of ethanol PSE microparticles is among 53-58%. The SASP process in our study was also extended to pilot plant scale (5L precipitator) which could produce PSE microparticles successfully.