目標：本研究目的旨在探討某醫學中心員工之工作壓力與健康相關生活品質。方法：採橫斷式調查研究並利用自填式問卷調查法蒐集相關資料，以中文版工作特質量表及臺灣版世界衛生組織生活品質問卷分別測量工作壓力與健康相關生活品質。研究母群為臺中某醫學中心之員工，採分層抽樣方法選取樣本500人進行問卷施測。結果：有關工作壓力部分，將近10%的員工屬於高壓力族群。而整體健康相關生活品質量表之得分為51.56，各分量表之得分為以生理健康範疇最高，環境範疇最低。將工作壓力與健康相關生活品質進行相關分析，結果顯示各分量表間大多數有顯著相關，且發現高壓力群之心理層面生活品質較低壓力群為差。再分析健康相關生活品質之預測因子，發現工作控制度、社會支持度、工作年資，以及職務之虛擬變項中護理人員與醫師等變項的影響達顯著水準，可以解釋48.2%的變異量。結論：衛生主管機關及醫務管理者應重視醫院員工之壓力問題，並提出有效的壓力管理策略，以預防壓力對醫院員工身心健康的傷害，並增進其身心健康與福祉。

　　　　　Objectives: The purpose of this study was to explore job strain and health related quality of life (HRQOL) for hospital employees in a medical center. Methods: A cross-sectional survey by self-administered questionnaires using the Chinese Version of the Job Content Questionnaire (C-JCQ) and the World Health Organization Quality of Life (WHOQOL) Taiwan version to measure job strain and HRQOL, respectively. Using stratified random sampling procedure, the survey data was collected from 500 employees working in a medical center located in Tai-Chung. Results: Slightly less than 10% of the employees in the sample had high-strain jobs. The overall score of HRQOL was 51.56, among four subscales, these employees scored highest on the physical health subscale and lowest on the environment subscale. The C-JCQ subscales and WHOQOL subscales were found to have a significantly highly correlation, and the high strain group was as likely to report a lack of quality of life on the psychological scale than the low strain group. In examining the predictors of HRQOL, it was found seniority, job control, work-related social support, physician dummy variable, and nurse dummy variable explained 48.2% of the variance in HRQOL. Conclusions: the findings in this study can help management executives and cabinet policy-makers to pinpoint the problem of job strain. They should build effective stress management strategies to avoid the stress hazards affect on the mental and physical health of employees, and to thereby improve employees' health and well-being.