目標：慢性疲勞是醫療院所最常見的病症之一，本研究旨在觀察病患所合併的身心症狀及人格特質。方法：研究蒐集102位因慢性疲勞至家庭醫學科門診就醫的病患以及70位健康對照組，施以自填式問卷調查。結果：慢性疲勞病患除具較高的精神情緒疾病(p＜0.001)、睡眠障礙(p＜0.001)、免疫力失調(p＜0.01)及消化性潰瘍病史(p＜0.05)外，其平均合併的身體心理情緒障礙症狀數高達12.13±6.36種，遠較對照組的3.03±3.63種高(p＜0.001)—半數以上的病患併有口乾、頸部僵硬、頭痛或頭暈、眼睛乾澀或模糊、記性變差、心神不寧以及注意力無法集中等症狀。病患在自評的性格上也較對照組易緊張、易操煩及易發脾氣(p＜0.05)。結論：鑒於此類病患症狀多樣化、其儀器檢查多無異樣發現，且部分病患病症與心理情緒因子有關，臨床醫師在處置病患時應採生理心理社會模式—除針對病患的生理症狀做診治外，也應顧及其心理、人個特質。

　　　　　Objectives: Chronic fatigue is one of the most common symptoms in medical care. This investigation is to explore the comorbidity of somatic ＆ psychiatric symptoms and personality characteristic of patients. Methods: 102 patients with chronic fatigue and 70 healthy controls were evaluated by self-reported questionnaire. Results: Those with chronic fatigue had a higher prevalence of psychiatric diseases(p＜0.001), sleep disturbance(p＜0.001), immune impairment(p＜0.01), and peptic ulcer(p＜0.05). The amount of psychosomatic symptoms of patients was significantly more than the control group(12.13±6.36 vs. 3.03±3.63, p＜0.001). There were more than half of the patients suffering from mouth dryness, neck tightness, poor memory, palpitation, headache or dizziness, eye dryness or blurred vision, irritability and poor concentration. The personality of patients showed more suspiciousness, sensitivity, and radicalism (p＜0.05). Conclusions: The symptoms of chronic fatigue patients frequently covered multiple organs without clear underlying medical explanations and related with psychological factors. Clinicians should approach chronic fatigue patients with a bio-psycho-social mode, intervening in patient掇 psychosocial variables as well as biological variables.