目標：探討金門縣社區性高尿酸血症盛行率及其相關危險因子。方法：於1991到1994年間，共11,922之30歲以上居民完成所有研究步驟。由熟練之訪員－陽明十字軍，進行結構式問卷調查，並由公共衛生護士採集禁食血液進行生化檢驗。以邏輯斯複迴歸模式分析高尿酸血症之相關危險因子。結果：篩檢率為59.3% (11,922/20,112)。高尿酸血症盛行率平均為25.4%，其中男性(尿酸值?.0 mg/dl )為31.0%，女性(尿酸值?.0 mg/dl)為20.9%。男性尿酸平均值為6.3±1.5 mg/dl，女性為5.0±1.4 mg/dl，男性高於女性。以性別和年齡分層探討相關危險因子，男女兩性30～39歲者之相關危險因子為高肌酸酐、高血脂、肥胖、高血壓，與女性停經。40歲以上者，除了上述相關危險因子之外，喝酒與使用利尿劑也是其極重要的危險因子。結論：高尿酸血症的相關危險因子會隨著性別與年齡而改變。利尿劑使用的重要性隨著年齡而上升。飲酒、停經與否、分別為男、女性的重要危險因子。

　　　　　Objectives: The purpose of present study was to investigate the prevalence and risk factors of hyperuricemia in Kinmen Island. Methods: A total of 11,922 residents aged ?0 years completed all examinations of the survey in Kinmen Island between 1991 and 1994. The response rate was 59.3% (11,922/20,112). The physical examination and structured questionnaire were carried out by the Yang-Ming Crusade, a group of well-trained medical students. Overnight fasting blood was collected by public health nurses. The risk factors of hyperuricemia were determined using multivariate logistic regression. Results: The crude prevalence of hyperuricemia, defined as serum uric acid ?.0mg/dl for men and ?.0mg/dl for women, was 25.4% (31.0% for men, 20.9% for women). The means and standard deviation of uric acid were 6.3?.5mg/dl for men and 5.0?.4mg/dl for women. Men had higher uric acid levels than women (p＜0.05). According to the age and sex spectrum, the risk factors of hyperuricemia were hyperlipidemia, high creatinine, obesity, and hypertension among young men and women, aged 30-39 years old and menopausal for women. Middle and old aged group (40-59 yrs and ?0 yrs) had the same risk factors as young aged group except alcohol consumption of man and the use of diuretics in both sexes. Conclusions: The risk factors of hyperuricemia were changed by sex and age. Use of diuretics became more important for middle-aged and elderly subjects. Alcohol consumption for men and menopausal for women were the most important risk factors of hyperuricemia.