漸逝波螢光生物感測器已發展了30多年，但在光學、生物化學與化學工程等領域，還是迫切地需要新的進展。近來有了突破性的發展，奈米金屬增強螢光技術有利於修改光譜特性與地緩光物理限制。筆者發展核殼奈米粒子(核:Ag 、殼:Si02)於光纖生物感測器之可能應用，其中螢光感測強度增進約50倍，此 外，四種不同的溶劑也影響螢光強度從1.3倍至100倍以上。

Evanescent wave fluorescent biosensors have developed for 30 years. Nonetheless， the technology continues to evolve with new breakthroughs in optics， biochemistry， and chemical engineering. Recently， there have been explosive developments in the metal-enhanced fluorescence (MEF) technology to favorably modify the spectral properties and to alleviate photo-physical constraints. We report the development of core-shell nanoparticles with the silver core and Si02 shell for potential applications in fiber optic biosensor. The fluorescence intensity was approximately 50-fold higher than that without core-shell nanoparticles doping. In addition， four different kinds of organic solvents are used in this study and found to have influence on the fluorescence intensity from 1.3 to over 100 times.